Shu-yang LI Hong Li Peng WANG Peng-zhen LIU Yong-Gang YAN
. 2015, 46(24): 22-0.
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Using sintering methods on the mixture of the calcium dihydrogen phosphate and calcium carbonate powder, and the calcium hydrogen phosphate and calcium sulfate powder, a series of calcium phosphate bioceramics materials were prepared. The samples were detected by XRD, FI-IR, degradation experiments, calcium and phosphorus ratio analysis, SEM observation and cytotoxicity test. Results showed that under the 750 ℃ sintering, calcium dihydrogen phosphate and calcium carbonate with 1:1 mole ratio generated calcium phosphate. When the molar ratios were 1:2 and 1:2.3, the calcium phosphate and hydroxyapatite bipolar biological ceramic were generated. Calcium hydrogen phosphate and calcium sulfate with molar ratios of 1:0.67 and 1:0.5 generated the calcium pyrophosphate and calcium sulfate bipolar biological ceramics. Degradation experiment showed that the weight loss of calcium pyrophosphate and calcium sulfate bipolar biological ceramics were 35% and 36%, respectively, after soaking in PBS for 28 days, and had no significant effect on the pH values of soaking liquid. Also the cytotoxicity test showed that the calcium pyrophosphate and calcium sulfate bipolar biological ceramics was non-toxic to cells.